The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3

Manira Rayamajhi; Edward A Miao

doi:10.1038/ni.3030

The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3

Nat Immunol. 2014 Dec;15(12):1100-2. doi: 10.1038/ni.3030.

Authors

Manira Rayamajhi¹, Edward A Miao¹

Affiliation

¹ Department of Microbiology and Immunology, the Lineberger Comprehensive Cancer Center and the Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

PMID: 25396345
PMCID: PMC5115691
DOI: 10.1038/ni.3030

Abstract

Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.

Publication types

News
Comment

MeSH terms

Animals
Carrier Proteins / immunology*
Humans
Inflammasomes / immunology*
NLR Family, Pyrin Domain-Containing 3 Protein
RNA Virus Infections / immunology*
Receptor-Interacting Protein Serine-Threonine Kinases / immunology*
Signal Transduction / immunology*

Substances

Carrier Proteins
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Nlrp3 protein, mouse
Receptor-Interacting Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

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