ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17

Nat Immunol. 2014 Dec;15(12):1099-100. doi: 10.1038/ni.3032.

Abstract

Chitinase-like proteins are associated with type 2 immune responses and the ‘wound-healing’ pathway, but their role has remained unclear. Studies have now highlighted their contribution to IL-17 production and their link to neutrophil activity required for the control of helminth infection.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Chitinase-3-Like Protein 1
  • Chitinases / immunology*
  • Glycoproteins / immunology*
  • Lectins / immunology*
  • Nematode Infections / immunology*
  • Neutrophil Infiltration / immunology*
  • beta-N-Acetylhexosaminidases / immunology*

Substances

  • Chil1 protein, mouse
  • Chitinase-3-Like Protein 1
  • Glycoproteins
  • Lectins
  • Chitinases
  • Ym2 protein, mouse
  • Chil3 protein, mouse
  • beta-N-Acetylhexosaminidases