Synthesis and cell phototoxicity of a triply bridged fused diporphyrin appended with six thioglucose units

Tetrahedron Lett. 2014 Nov 12;55(46):6311-6314. doi: 10.1016/j.tetlet.2014.09.085. Epub 2014 Sep 28.

Abstract

A triply bridged fused diporphyrin appended with six thioglucose units is reported. This new, chemically and photochemically stable amphiphilic compound is taken up by breast cancer cells and causes cell death upon light exposure. Photophysical studies reveal absorption bands in the near IR region, and photosensitized formation of singlet oxygen in high quantum yields.

Keywords: Click Chemistry; Fluorescence; Photodynamic Therapy; Porphyrin; Thioglucose.