Background: Interferon-associated retinopathy is a rare complication of interferon treatment. It has been well described with the use of interferon-α.
Methods: This study reports a retrospective case series of interferon-β-associated retinopathy in three patients that were being treated for multiple sclerosis.
Results: All cases were characterized by cotton-wool spots or peripheral microaneurysms. One central retinal artery occlusion was observed associated with interferon-β treatment. Findings improved spontaneously in two of three cases; all three patients elected to continue interferon treatment.
Conclusion: Patients being treated with interferon-β should have periodic fundus examinations to determine if they have evidence of interferon-associated retinopathy.