We present new approaches to improve the efficiency of DNA by scanning probe microscopy using a highly specific hybridization on affine surfaces and nanostructures of gold as a labels. Scanning probe microscopy allows to register of individual acts of hybridization by the detection of gold labels on the surface affinity followed by automatic calculation of the total.
Predstavleny novye podkhody, napravlennye na povyshenie éffektivnosti opredeleniia DNK metodom skaniruiushcheĭ zondovoĭ mikroskopii s ispol'zovaniem vysokospetsifichnoĭ gibridizatsii na affinnykh poverkhnostiakh i nanostruktur zolota v kachestve metki. Skaniruiushchaia zondovaia mikroskopiia pozvoliaet po obnaruzheniiu zolotykh metok na affinnoĭ poverkhnosti registrirovat' edinichnye akty gibridizatsii s posleduiushchim avtomaticheskim podschetom ikh obshchego chisla.
Keywords: DNA-biosensor; analysis and image processing; highly specific hybridization; nanoparticles; scanning probe microscopy.