Description of the OXA-23 β-lactamase gene located within Tn2007 in a clinical isolate of Acinetobacter baumannii from Spain

Microb Drug Resist. 2015 Apr;21(2):215-7. doi: 10.1089/mdr.2014.0155. Epub 2014 Nov 11.

Abstract

A carbapenem-resistant Acinetobacter baumannii expressing blaOXA-23 was recovered from an intensive care unit patient in a third-level hospital from Spain. Genetic analysis showed the association of this carbapenemase with the transposon Tn2007 located in a plasmid of 10 kb. The isolate was classified as ST-1. This strain has shown a potential ability to displace other endemic strains in the hospital and is the first reported identification of A. baumannii carrying blaOXA-23 related to Tn2007 in Spain.

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification*
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins / genetics
  • Carbapenems / therapeutic use
  • Cross Infection / drug therapy
  • Cross Infection / microbiology
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Imipenem / therapeutic use
  • Male
  • Microbial Sensitivity Tests / methods
  • Spain
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • DNA Transposable Elements
  • Imipenem
  • beta-lactamase OXA-23
  • beta-Lactamases
  • carbapenemase