A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Chunpu Li; Lei Zhang; Shuangjie Shu; Hong Liu

doi:10.3762/bjoc.10.254

A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Beilstein J Org Chem. 2014 Oct 21:10:2441-7. doi: 10.3762/bjoc.10.254. eCollection 2014.

Authors

Chunpu Li¹, Lei Zhang², Shuangjie Shu², Hong Liu¹

Affiliations

¹ Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China ; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
² CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.

Abstract

A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C-C and C-N coupling. This protocol provides an operationally simple and rapid strategy for preparing indolo[1,2-a]quinazoline derivatives and displays good functional group tolerance. All the starting materials are commercial available or can be easily prepared.

Keywords: copper; one pot; synthetic methods.