Abstract
Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport
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CHO Cells
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Cell Line, Tumor
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Cricetinae
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Cricetulus
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Female
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Flow Cytometry
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Fructose / chemistry*
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Glucose Transporter Type 5 / metabolism
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Humans
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MCF-7 Cells
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Mice
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Micelles
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Microscopy, Confocal
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Nanoparticles / chemistry
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Nanoparticles / metabolism*
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Polymers / chemistry
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Protein Binding
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Triple Negative Breast Neoplasms / metabolism
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Triple Negative Breast Neoplasms / pathology
Substances
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Glucose Transporter Type 5
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Micelles
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Polymers
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SLC2A5 protein, human
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Fructose