Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

Chem Commun (Camb). 2014 Dec 28;50(100):15928-31. doi: 10.1039/c4cc06651k.

Abstract

Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • CHO Cells
  • Cell Line, Tumor
  • Cricetinae
  • Cricetulus
  • Female
  • Flow Cytometry
  • Fructose / chemistry*
  • Glucose Transporter Type 5 / metabolism
  • Humans
  • MCF-7 Cells
  • Mice
  • Micelles
  • Microscopy, Confocal
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism*
  • Polymers / chemistry
  • Protein Binding
  • Triple Negative Breast Neoplasms / metabolism
  • Triple Negative Breast Neoplasms / pathology

Substances

  • Glucose Transporter Type 5
  • Micelles
  • Polymers
  • SLC2A5 protein, human
  • Fructose