Dysidinoid A, an unusual meroterpenoid with anti-MRSA activity from the South China Sea sponge Dysidea sp

Molecules. 2014 Nov 5;19(11):18025-32. doi: 10.3390/molecules191118025.

Abstract

An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 μg/mL against both.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / isolation & purification
  • Anti-Infective Agents* / pharmacology
  • China
  • Methicillin-Resistant Staphylococcus aureus / growth & development*
  • Oceans and Seas
  • Porifera / chemistry*
  • Terpenes* / chemistry
  • Terpenes* / isolation & purification
  • Terpenes* / pharmacology

Substances

  • Anti-Infective Agents
  • Terpenes