Hit the spleen, JAK!

Blood. 2014 Nov 6;124(19):2898-900. doi: 10.1182/blood-2014-09-600635.

Abstract

In this issue of Blood, Wang et al report on the response of splenic-derived hematopoietic stem and progenitor cells from patients with myelofibrosis (MF) to the Janus kinase (JAK) inhibitor, AZD1480.

Publication types

  • Comment

MeSH terms

  • Female
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors*
  • Male
  • Primary Myelofibrosis / drug therapy*
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*
  • Spleen / cytology*
  • Stem Cells / drug effects*

Substances

  • AZD 1480
  • Pyrazoles
  • Pyrimidines
  • JAK2 protein, human
  • Janus Kinase 2