Objective: To investigate the values of CD64 and CD11b indices of peripheral white blood cells in the early diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) in older adults.
Methods: The study enrolled 86 aged AE-COPD patients, 82 stable-COPD patients admitted in the affiliated hospital of Jiujiang University from March 2011 to December 2013, and simultaneously 84 healthy aged volunteers as a control group. All the subjects were examined in white blood cells, hypersensitive C-reactive protein (hs-CRP), mean fluorescence intensity (MFI) of CD64 and CD11b from peripheral white blood cells within 24 hours after admission. CD64 and CD11b MFI were converted into CD64 and CD11b indices by conversion formula. The significant indicators for the diagnosis of AE-COPD were screened and the receiver operating characteristic (ROC) curve was drawn for calculating the area under the curve, critical value, sensitivity and specificity.
Results: Compare with stable-COPD group, the CD11b index decreased and CD64 index increased. There existed statistical difference in CD11b and CD64 indices between the AE-COPD group and the stable-COPD group (P<0.01), but not between the stable-COPD group and the healthy control group (P>0.05). Critical values of CD11b and CD64 indices were respectively less than 0.94 and more than 1.83. Their sensitively and specificity for the diagnosis of AE-COPD were 62.65% and 77.11% for CD11b and 79.52% and 98.80% for CD64.
Conclusion: Increased CD64 index and decreased CD11b index are the credible laboratory markers in the early diagnosis of AE-COPD, and the dynamic monitoring of them may facilitate the evaluation of therapeutic outcomes of AE-COPD.