Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design

Sebusi Odisitse; Graham E Jackson

doi:10.1155/2014/863612

Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design

Bioinorg Chem Appl. 2014:2014:863612. doi: 10.1155/2014/863612. Epub 2014 Oct 12.

Authors

Sebusi Odisitse¹, Graham E Jackson²

Affiliations

¹ Department of Chemistry, University of Cape Town, Private Bag X3, Rondebosch, Cape Town 7701, South Africa ; Natural Resources and Materials, Botswana Institute for Technology Research and Innovation, Plot 50654 Machel Drive, Private Bag 0082, Gaborone, Botswana.
² Department of Chemistry, University of Cape Town, Private Bag X3, Rondebosch, Cape Town 7701, South Africa.

Abstract

The thermodynamic equilibria of nickel(II) with N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N'-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm(-3) by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.