Role of nanocrystalline silver dressings in the management of toxic epidermal necrolysis (TEN) and TEN/Stevens-Johnson syndrome overlap

Australas J Dermatol. 2015 Nov;56(4):298-302. doi: 10.1111/ajd.12254. Epub 2014 Nov 4.

Abstract

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe mucocutaneous eruptions. There is currently no defined optimal approach to wound care. The objective of this study was to evaluate silver dressings in the wound-care management of TEN and SJS/TEN syndrome overlap with a retrospective case review of nine patients with TEN and SJS/TEN overlap presenting to our institution. Nanocrystalline silver dressings appear to be useful in the rapid commencement of healing in these patients. TEN and SJS/TEN overlap are rare conditions. This contributed to a relatively small number of cases included in the study. The ease of application, antimicrobial properties and low frequency of change make nanocrystalline silver dressings ideal in TEN/SJS.

Keywords: Stevens-Johnson syndrome; dressing; drug eruption; nanocrystalline silver; toxic epidermal necrolysis; wound care.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bandages*
  • Female
  • Humans
  • Male
  • Metal Nanoparticles*
  • Middle Aged
  • Retrospective Studies
  • Severity of Illness Index
  • Silver / therapeutic use*
  • Stevens-Johnson Syndrome / drug therapy*
  • Young Adult

Substances

  • Silver