End-of-life pain medication among cancer patients in hospice settings

Anticancer Res. 2014 Nov;34(11):6581-4.

Abstract

Cancer pain management in a hospice setting was studied in the present article. Drug treatments were studied at five time points: at the time of transfer to hospice, at 2nd day, two weeks, and two months following transfer to hospice care, as well as one day before death.

Patients and methods: Records of 138 consecutive cancer patients treated in hospice in 2010 were studied regarding the drugs given during their stay. The most common cancer was gastro-intestinal cancer (33%), followed by lung (16%) and breast cancer (11%). Data were collected from patients' records and coded in a validated manner for statistical analysis.

Results: The median length of stay in hospice was 14 days (range=2-376 days). Upon transfer, 63% of patients were administered regularly-dosed opioids, 76.8% during the second day at hospice, and 89.9% of the patients received opioids one day prior to death. A significant change was observed in the more frequent subcutaneous administration during hospice stay (p<0.0001). Break-through pain was recorded on the second day in hospice by 52 % of patients, and by 76% on the day prior to death.

Conclusion: Individual patients' needs determined the dose range, but this was not the case for administration route of strong opioids during hospice care.

Keywords: End-of-life care; hospice; opioids; pain.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid / therapeutic use*
  • Female
  • Follow-Up Studies
  • Hospice Care*
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / therapy
  • Pain / drug therapy*
  • Pain / etiology
  • Prognosis
  • Terminal Care*

Substances

  • Analgesics, Opioid