Abstract
A new phenolic glycoside (1), named methyl 2-phenylpropanoate-2-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, was isolated from the barks of Cinnamomum cassia, along with three known phenolic glycosides and four known lignan glycosides. The structure of 1 was elucidated by extensive interpretation of spectroscopic data and chemical method. Selected compounds were evaluated for their immunosuppressive activities against murine lymphocytes. Compounds 1, 2, 6 and 8 exhibited differential inhibition against ConA-induced T cells proliferation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Cells, Cultured
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Cinnamomum aromaticum / chemistry*
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Glycosides / chemistry*
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Glycosides / pharmacology*
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Lignans / chemistry
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy / methods
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Mice
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Molecular Structure
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Phenols / chemistry*
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Phenols / pharmacology*
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Plant Bark / chemistry*
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T-Lymphocytes / drug effects
Substances
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Glycosides
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Immunosuppressive Agents
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Lignans
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Phenols