Missed opportunities for early access to care of HIV-infected infants in Burkina Faso

PLoS One. 2014 Oct 31;9(10):e111240. doi: 10.1371/journal.pone.0111240. eCollection 2014.

Abstract

Objective: The World Health Organization (WHO) has recommended a universal antiretroviral therapy (ART) for all HIV-infected children before the age of two since 2010, but this implies an early identification of these infants. We described the Prevention of Mother-to-Child HIV Transmission (PMTCT) cascade, the staffing and the quality of infrastructures in pediatric HIV care facilities, in Ouagadougou, Burkina Faso.

Methods: We conducted a cross-sectional survey in 2011 in all health care facilities involved in PMTCT and pediatric HIV care in Ouagadougou. We assessed them according to their coverage in pediatric HIV care and WHO standards, through a desk review of medical registers and a semi-structured questionnaire administered to health-care workers (HCW).

Results: In 2011, there was no offer of care in primary health care facilities for HIV-infected children in Ouagadougou. Six district hospitals and two university hospitals provided pediatric HIV care. Among the 67 592 pregnant women attending antenatal clinics in 2011, 85.9% were tested for HIV. The prevalence of HIV was 1.8% (95% Confidence Interval: 1.7%-1.9%). Among the 1 064 HIV-infected pregnant women attending antenatal clinics, 41.4% received a mother-to-child HIV transmission prevention intervention. Among the HIV-exposed infants, 313 (29.4%) had an early infant HIV test, and 306 (97.8%) of these infants tested received their result within a four-month period. Among the 40 children initially tested HIV-infected, 33 (82.5%) were referred to a health care facility, 3 (9.0%) were false positive, and 27 (90.0%) were initiated on ART. Although health care facilities were adequately supplied with HIV drugs, they were hindered by operational challenges such as shortage of infrastructures, laboratory reagents, and trained HCW.

Conclusions: The PMTCT cascade revealed bottle necks in PMTCT intervention and HIV early infant diagnosis. The staffing in HIV care and quality of health care infrastructures were also insufficient in 2011 in Ouagadougou.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Burkina Faso / epidemiology
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / epidemiology*
  • HIV Infections / transmission
  • Health Services Accessibility / statistics & numerical data*
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical / prevention & control
  • Male
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy

Substances

  • Anti-HIV Agents

Grants and funding

The study was supported in part by the MONOD ANRS 12206 project granted by the European and Developing Countries Clinical Trial Partnership (EDCTP), the CRP-santé in Luxembourg and the French ANRS-Inserm. Dr. Malik Coulibaly is a fellow PhD candidate of the Doctoral School of Society, Politics and Public Health, Bordeaux, France funded by the MONOD consortium. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.