This MMWR Supplement presents data related to disease patterns across the United States and describes recent national trends in health status. Indicators of health status (i.e., measures of observed or calculated data on the status of a health condition) were chosen to reflect the range of health issues relevant to CDC's programs that are used across the agency to monitor health. In response to the status of these health issues, CDC works with state and local health systems across the United States on these diseases and others to save lives and protect persons.