Advances in metal-catalyzed cross-coupling reactions of halogenated quinazolinones and their quinazoline derivatives

Malose Jack Mphahlele; Marole Maria Maluleka

doi:10.3390/molecules191117435

Advances in metal-catalyzed cross-coupling reactions of halogenated quinazolinones and their quinazoline derivatives

Molecules. 2014 Oct 29;19(11):17435-63. doi: 10.3390/molecules191117435.

Authors

Malose Jack Mphahlele¹, Marole Maria Maluleka²

Affiliations

¹ Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. mphahmj@unisa.ac.za.
² Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. malulmm@unisa.ac.za.

Abstract

Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon-carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview of the application of these methods on halogenated quinazolin-4-ones and their quinazolines to generate novel polysubstituted derivatives.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carbon / chemistry
Catalysis
Halogenation
Halogens / chemistry*
Metals / chemistry*
Quinazolines / chemistry*
Quinazolinones / chemistry*

Substances

Halogens
Metals
Quinazolines
Quinazolinones
Carbon