Indole alkaloids with new skeleton activating neural stem cells

Org Lett. 2014 Nov 7;16(21):5808-11. doi: 10.1021/ol5029223. Epub 2014 Oct 29.

Abstract

Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 μg/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alstonia / chemistry*
  • Cell Differentiation
  • Cell Proliferation / drug effects*
  • Heterocyclic Compounds, 4 or More Rings / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification
  • Heterocyclic Compounds, 4 or More Rings / metabolism*
  • Indole Alkaloids / chemistry*
  • Indoles / chemistry*
  • Indoles / isolation & purification
  • Indoles / metabolism*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neural Stem Cells / chemistry*
  • Neural Stem Cells / cytology*
  • Neural Stem Cells / metabolism
  • Plant Leaves
  • Secologanin Tryptamine Alkaloids / chemistry*
  • Secologanin Tryptamine Alkaloids / isolation & purification
  • Secologanin Tryptamine Alkaloids / metabolism
  • Wnt Signaling Pathway / drug effects
  • Wnt Signaling Pathway / physiology*

Substances

  • Heterocyclic Compounds, 4 or More Rings
  • Indole Alkaloids
  • Indoles
  • Secologanin Tryptamine Alkaloids
  • alistonitrine A
  • alstoscholarine