Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation

Xu Wang; Jianzheng Lv; Xueying Yao; Yong Li; Fang Huang; Mengmeng Li; Jie Yang; Xiuyun Ruan; Bo Tang

doi:10.1039/c4cc06637e

Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation

Chem Commun (Camb). 2014 Dec 18;50(97):15439-42. doi: 10.1039/c4cc06637e. Epub 2014 Oct 29.

Authors

Xu Wang¹, Jianzheng Lv, Xueying Yao, Yong Li, Fang Huang, Mengmeng Li, Jie Yang, Xiuyun Ruan, Bo Tang

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China. tangb@sdnu.edu.cn.

PMID: 25351858
DOI: 10.1039/c4cc06637e

Abstract

Here we report the synthesis and screening of Cy-3-NO2 that showed simultaneous fluorescence sensing ability towards glutathione and cysteine under single excitation, and its application in living cell imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cysteine / analysis*
Cysteine / chemistry
Fluorescent Dyes* / chemical synthesis
Fluorescent Dyes* / chemistry
Fluorescent Dyes* / pharmacology
Glutathione / analysis*
Glutathione / chemistry
HeLa Cells
Humans
Microscopy, Confocal

Substances

Fluorescent Dyes
Glutathione
Cysteine