A ratiometric fluorescent probe with unexpected high selectivity for ATP and its application in cell imaging

Chem Commun (Camb). 2014 Dec 18;50(97):15411-4. doi: 10.1039/c4cc08044k. Epub 2014 Oct 28.

Abstract

Naphthalimide-rhodamine compound (NR) is developed as a ratiometric fluorescent probe for ATP detection based on the FRET mechanism. It shows an unexpected high selectivity for ATP over other anions, especially organic phosphate anions, due to simultaneous interactions of two recognition sites, which benefits fluorescence imaging in living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / analysis*
  • Adenosine Triphosphate / chemistry
  • Colorimetry
  • Fluorescence Resonance Energy Transfer
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Naphthalimides / chemistry*
  • Optical Imaging
  • Rhodamines / chemistry*

Substances

  • Fluorescent Dyes
  • Naphthalimides
  • Rhodamines
  • Adenosine Triphosphate