Probing structural changes of self assembled i-motif DNA

Chem Commun (Camb). 2015 Mar 4;51(18):3747-9. doi: 10.1039/c4cc06824f.

Abstract

We report an i-motif structural probing system based on Thioflavin T (ThT) as a fluorescent sensor. This probe can discriminate the structural changes of RET and Rb i-motif sequences according to pH change.

MeSH terms

  • Benzothiazoles
  • Biosensing Techniques
  • Circular Dichroism
  • Fluorescent Dyes / analysis*
  • Hydrogen-Ion Concentration
  • Nucleotide Motifs*
  • Proto-Oncogene Proteins c-ret / genetics*
  • Retinoblastoma Protein / genetics*
  • Spectrometry, Fluorescence
  • Thiazoles / analysis*

Substances

  • Benzothiazoles
  • Fluorescent Dyes
  • Retinoblastoma Protein
  • Thiazoles
  • thioflavin T
  • Proto-Oncogene Proteins c-ret