Azobenzene-based chloride transporters with light-controllable activities

Chem Commun (Camb). 2014 Dec 18;50(97):15305-8. doi: 10.1039/c4cc07560a. Epub 2014 Oct 28.

Abstract

Synthetic chloride transporters containing two urea groups linked through a diazobenzene spacer have been prepared and the trans-to-cis isomerization by light stimulation results in dramatic changes in the chloride transport activities across lipid and cell membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Azo Compounds / chemistry*
  • Azo Compounds / radiation effects
  • Biological Transport
  • Cell Line
  • Cell Membrane / metabolism
  • Drug Carriers / administration & dosage
  • Drug Carriers / chemistry
  • Drug Carriers / pharmacokinetics
  • Drug Carriers / radiation effects
  • Isomerism
  • Rats, Inbred F344
  • Sodium Chloride / administration & dosage
  • Sodium Chloride / chemistry*
  • Sodium Chloride / pharmacokinetics
  • Ultraviolet Rays
  • Urea / chemistry

Substances

  • Azo Compounds
  • Drug Carriers
  • Sodium Chloride
  • Urea
  • azobenzene