A lithium-rich composite metal oxide used as a SALDI-MS matrix for the determination of small biomolecules

Chem Commun (Camb). 2014 Dec 18;50(97):15397-9. doi: 10.1039/c4cc07479c. Epub 2014 Oct 28.

Abstract

A lithium-rich composite metal oxide was evaluated as a novel matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). The low background interference and lithium-rich feature made it a highly efficient matrix for the analysis of small molecules with high reproducibility, sensitivity and strong salt tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry
  • Citric Acid / chemistry
  • Cyclodextrins / analysis
  • Cyclodextrins / chemistry
  • Edetic Acid / chemistry
  • Gliclazide / analysis
  • Gliclazide / chemistry
  • Glipizide / analysis
  • Glipizide / chemistry
  • Lipids / analysis
  • Lipids / chemistry
  • Lithium / chemistry*
  • Oligosaccharides / analysis
  • Oligosaccharides / chemistry
  • Oxides / chemistry*
  • Peptides / analysis
  • Peptides / chemistry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*

Substances

  • Chelating Agents
  • Cyclodextrins
  • Lipids
  • Oligosaccharides
  • Oxides
  • Peptides
  • Citric Acid
  • Lithium
  • Edetic Acid
  • Gliclazide
  • Glipizide