Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo

Chem Commun (Camb). 2014 Dec 18;50(97):15423-6. doi: 10.1039/c4cc05614k. Epub 2014 Oct 28.

Abstract

A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg-Gly-Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacokinetics
  • Breast Neoplasms / metabolism
  • Cell Survival / drug effects
  • Coloring Agents / chemistry
  • Drug Carriers* / administration & dosage
  • Drug Carriers* / chemistry
  • Drug Carriers* / pharmacokinetics
  • Estrone* / administration & dosage
  • Estrone* / chemistry
  • Estrone* / pharmacokinetics
  • Female
  • Humans
  • Hydrogels* / administration & dosage
  • Hydrogels* / chemistry
  • Hydrogels* / pharmacokinetics
  • Indocyanine Green / chemistry
  • MCF-7 Cells
  • Mice, Nude
  • Oligopeptides* / administration & dosage
  • Oligopeptides* / chemistry
  • Oligopeptides* / pharmacokinetics
  • Paclitaxel / administration & dosage*
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacokinetics

Substances

  • Antineoplastic Agents, Phytogenic
  • Coloring Agents
  • Drug Carriers
  • Hydrogels
  • Oligopeptides
  • Estrone
  • arginyl-glycyl-aspartic acid
  • Indocyanine Green
  • Paclitaxel