Abstract
Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Membrane / metabolism
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Fluorescein / chemistry
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Fluorescein / pharmacology*
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Kidney Tubules / cytology
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Mice
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Mitochondria / metabolism*
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / pharmacology*
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Protons
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Rats
Substances
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Fluorescent Dyes
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Organophosphorus Compounds
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Protons
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Fluorescein