Association of class 1 and 2 integrons with multidrug-resistant Acinetobacter baumannii international clones and Acinetobacter nosocomialis isolates

Antimicrob Agents Chemother. 2015 Jan;59(1):698-701. doi: 10.1128/AAC.02415-14. Epub 2014 Oct 27.

Abstract

The Acinetobacter baumannii clonal complex 113/79 (CC113/79) and class 2 integrons predominate in Latin America; a relationship between these characteristics was explored. The presence of integrases was determined in successive hospital Acinetobacter isolates (163 A. baumannii isolates and 72 Acinetobacter nosocomialis isolates). Most isolates had integrons, but class 1 and 2 integrons were present significantly more often in CC109/1 and CC113/79, respectively. The high prevalence of CC113/79 in Latin America may account for the predominance of class 2 integrons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects*
  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Genes, Bacterial / genetics
  • Genotype
  • Humans
  • Integrons / genetics*

Substances

  • Anti-Bacterial Agents