Bortezomib is a rapid mobilizer of hematopoietic stem cells in mice via modulation of the VCAM-1/VLA-4 axis

Blood. 2014 Oct 23;124(17):2752-4. doi: 10.1182/blood-2014-08-595967.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Benzylamines
  • Boronic Acids / pharmacology*
  • Bortezomib
  • Cyclams
  • Drug Synergism
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Hematopoietic Stem Cell Mobilization / methods*
  • Hematopoietic Stem Cells / drug effects*
  • Hematopoietic Stem Cells / metabolism
  • Heterocyclic Compounds / pharmacology
  • Integrin alpha4beta1 / genetics
  • Integrin alpha4beta1 / metabolism*
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Proteasome Inhibitors / pharmacology
  • Pyrazines / pharmacology*
  • Time Factors
  • Vascular Cell Adhesion Molecule-1 / metabolism*

Substances

  • Benzylamines
  • Boronic Acids
  • Cyclams
  • Heterocyclic Compounds
  • Integrin alpha4beta1
  • Proteasome Inhibitors
  • Pyrazines
  • Vascular Cell Adhesion Molecule-1
  • Granulocyte Colony-Stimulating Factor
  • Bortezomib
  • plerixafor