Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes

Int J Clin Exp Pathol. 2014 Aug 15;7(9):5436-49. eCollection 2014.

Abstract

Drug-loaded electrospun PLLA membranes are not conducive to adhesion between materials and tissues due to the strong hydrophobicity of PLLA, which possibly attenuate the drugs' effect loaded on the materials. In the present work, we developed a facile method to improve the hydrophilicity of doxorubicin (DOX)-loaded electrospun PLLA fibrous membranes, which could enhance the anti-tumor effect at the early stage after implantation. A mussel protein, polydopamine (PDA), could be easily grafted on the surface of hydrophobic DOX-loaded electrospun PLLA membranes (PLLA-DOX/pDA) in water solution. The morphology analysis of PLLA-DOX/pDA fibers displayed that though the fiber diameter was slightly swollen, they still maintained a 3D fibrous structure, and the XPS analysis certified that pDA had successfully been grafted onto the surface of the fibers. The results of surface wettability analysis showed that the contact angle decreased from 136.7° to 0° after grafting. In vitro MTT assay showed that the cytotoxicity of PLLA-DOX/pDA fibers was the strongest, and the stereologic cell counting assay demonstrated that the adhesiveness of PLLA/pDA fiber was significantly better than PLLA fiber. In vivo tumor-bearing mice displayed that, after one week of implantation, the tumor apoptosis and necrosis of PLLA-DOX/pDA fibers were the most obvious from histopathology and TUNEL assay. The caspase-3 activity of PLLA-DOX/pDA group was the highest using biochemical techniques, and the Bax: Bcl-2 ratio increased significantly in PLLA-DOX/pDA group through qRT-PCR analysis. All the results demonstrated that pDA can improve the affinity of the electrospun PLLA membranes and enhance the drug effect on tumors.

Keywords: Cancer; PLLA; electrospun; hydrophobicity; polydopamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology*
  • Apoptosis / drug effects
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Caspase 3 / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Chemistry, Pharmaceutical
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Carriers*
  • Drug Implants
  • Female
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Indoles / chemistry*
  • Lactic Acid / chemistry*
  • Membranes, Artificial*
  • Mice, Inbred BALB C
  • Mice, Nude
  • Molecular Conformation
  • Necrosis
  • Polyesters
  • Polymers / chemistry*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Surface Properties
  • Time Factors
  • Xenograft Model Antitumor Assays
  • bcl-2-Associated X Protein / metabolism

Substances

  • Antibiotics, Antineoplastic
  • BAX protein, human
  • BCL2 protein, human
  • Drug Carriers
  • Drug Implants
  • Indoles
  • Membranes, Artificial
  • Polyesters
  • Polymers
  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2-Associated X Protein
  • polydopamine
  • Lactic Acid
  • poly(lactide)
  • Doxorubicin
  • CASP3 protein, human
  • Caspase 3