The spectacular advances in diagnostic imaging technologies, such as CT, MRI, and NM, have improved the quality of radiological diagnosis. On the other hand, the vast amount of image data produced by these digital modalities have created unique problems in managing the information. The increased use of digital imaging systems has set the stage for the development of comprehensive medical image and information management systems for large medical facilities. These image management and communication systems (IMACS) vary, depending on imaging, display and output devices connected, network configurations used, and storage devices available. This paper will discuss the important technical aspects in developing an IMACS network, imaging devices ideally suited for connection to an IMACS, integration with computerized hospital and radiology information systems, performance issues, clinical acceptance and specific implementation experience.