Abstract
Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed appreciable cytotoxicity toward KB cells (IC50 ca. 5 μg/mL). The structure of the known Tabernaemontana alkaloid tronoharine (8) was revised based on newly acquired NMR data, as well as X-ray diffraction analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology*
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Indoles / chemistry
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Indoles / isolation & purification
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Indoles / pharmacology
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Malaysia
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pausinystalia
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Plants, Medicinal / chemistry*
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Tabernaemontana / chemistry*
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Tryptamines / chemistry
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Tryptamines / isolation & purification
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Tryptamines / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Indole Alkaloids
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Indoles
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Tryptamines
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tacaman
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vobasine
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tryptamine