Detection of new or rapidly evolving melanocytic lesions is crucial for early diagnosis and treatment of melanoma. We propose a fully automated pre-screening system for detecting new lesions or changes in existing ones, on the order of 2 - 3mm, over almost the entire body surface. Our solution is based on a multi-camera 3D stereo system. The system captures 3D textured scans of a subject at different times and then brings these scans into correspondence by aligning them with a learned, parametric, non-rigid 3D body model. This means that captured skin textures are in accurate alignment across scans, facilitating the detection of new or changing lesions. The integration of lesion segmentation with a deformable 3D body model is a key contribution that makes our approach robust to changes in illumination and subject pose.