Joint parametric reconstruction and motion correction framework for dynamic PET data

Med Image Comput Comput Assist Interv. 2014;17(Pt 1):114-21. doi: 10.1007/978-3-319-10404-1_15.

Abstract

In this paper we propose a novel algorithm for jointly performing data based motion correction and direct parametric reconstruction of dynamic PET data. We derive a closed form update for the penalised likelihood maximisation which greatly enhances the algorithm's computational efficiency for practical use. Our algorithm achieves sub-voxel motion correction residual with noisy data in the simulation-based validation and reduces the bias of the direct estimation of the kinetic parameter of interest. A preliminary evaluation on clinical brain data using [18F]Choline shows improved contrast for regions of high activity. The proposed method is based on a data-driven kinetic modelling method and is directly applicable to reversible and irreversible PET tracers, covering a range of clinical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artifacts*
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Choline / analogs & derivatives*
  • Choline / pharmacokinetics
  • Computer Simulation
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods
  • Models, Biological
  • Motion
  • Positron-Emission Tomography / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • fluoromethylcholine
  • Choline