Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

Chem Commun (Camb). 2015;51(2):273-275. doi: 10.1039/c4cc07278b.

Abstract

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell-Penetrating Peptides / chemistry*
  • Gold / chemistry*
  • Hydrogen-Ion Concentration
  • Immobilized Proteins / chemistry
  • Metal Nanoparticles / chemistry*
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Protein Structure, Secondary
  • Surface Properties

Substances

  • Cell-Penetrating Peptides
  • Immobilized Proteins
  • Peptides
  • GALA peptide
  • Gold