Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

Adv Mater. 2014 Dec 3;26(45):7615-21. doi: 10.1002/adma.201401554. Epub 2014 Oct 18.

Abstract

A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.

Keywords: biomedical applications; dendrimers; drug delivery; lipids; nanomedicine; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Cell Line, Tumor
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Cholesterol / chemistry
  • Dendrimers*
  • Doxorubicin / administration & dosage
  • Drug Delivery Systems / methods*
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Micelles
  • Nanomedicine / methods
  • Nanostructures / chemistry*
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / metabolism
  • Phosphatidylethanolamines / chemistry
  • Polyethylene Glycols / chemistry

Substances

  • Antineoplastic Agents
  • Dendrimers
  • Micelles
  • Phosphatidylethanolamines
  • 1,2-distearoylphosphatidylethanolamine
  • dioleoyl phosphatidylethanolamine
  • Polyethylene Glycols
  • Doxorubicin
  • Cholesterol