Micropatterning of hydrophilic polyacrylamide brushes to resist cell adhesion but promote protein retention

Jianwen Hou; Qiang Shi; Wei Ye; Paola Stagnaro; Jinghua Yin

doi:10.1039/c4cc03994g

Micropatterning of hydrophilic polyacrylamide brushes to resist cell adhesion but promote protein retention

Chem Commun (Camb). 2014 Dec 11;50(95):14975-8. doi: 10.1039/c4cc03994g.

Authors

Jianwen Hou¹, Qiang Shi, Wei Ye, Paola Stagnaro, Jinghua Yin

Affiliation

¹ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. shiqiang@ciac.ac.cn yinjh@ciac.ac.cn.

PMID: 25328048
DOI: 10.1039/c4cc03994g

Abstract

Contrary to a prevailing concept on protein adsorption and cell adhesion, novel micropatterned polyacrylamide (PAAm) brushes that can resist cell adhesion but promote protein retention are created through patterning of ATRP initiators and surface-initiated ATRP on a polymer substrate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemistry*
Animals
Blood Platelets / chemistry*
Blood Proteins / chemistry*
Cattle
Cell Adhesion
Erythrocytes / chemistry*
Hydrophobic and Hydrophilic Interactions
Polyethylenes / chemistry*
Polystyrenes / chemistry*
Surface Properties

Substances

Acrylic Resins
Blood Proteins
Polyethylenes
Polystyrenes
styrene-ethylene-butylene-styrene-block copolymer
polyacrylamide