Rhodium(III)-catalysed aerobic synthesis of highly functionalized indoles from N-arylurea under mild conditions through C-H activation

Chem Commun (Camb). 2014 Dec 11;50(95):14964-7. doi: 10.1039/c4cc06020b.

Abstract

A Rh(III) catalysed amino arylation of alkynes using copper as the terminal oxidant for regeneration of the catalytically active species under aerobic conditions is described. This novel C-H activation reaction was applied to the synthesis of a wide range of substituted indoles from N-arylureas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Copper / chemistry
  • Indoles / chemical synthesis*
  • Oxidants / chemistry
  • Rhodium / chemistry*
  • Urea / analogs & derivatives*
  • Urea / chemistry*

Substances

  • Alkynes
  • Indoles
  • Oxidants
  • Copper
  • Urea
  • Rhodium