Cardiac inflammatory myofibroblastic tumor: a comprehensive review of the literature

World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):556-64. doi: 10.1177/2150135114546203.

Abstract

Although inflammatory myofibroblastic tumors (IMTs) can be found in virtually every major organ, cardiac origin is rare. After recently providing care to a child who presented with a significant myocardial infarction, interest in this rare tumor was piqued. We describe a comprehensive review of cardiac IMT, including information on nomenclature, epidemiology, clinical features, pathogenesis, gross/histological features, immunohistochemical profile, diagnosis, treatment, and prognosis. Fifty-seven cases were identified in the literature. Interestingly, our case represents the seventh case of coronary artery involvement reported. Moreover, it was found that an initial presentation of sudden death most commonly involves the coronary arteries.

Keywords: cardiac; inflammatory myofibroblastic tumor; inflammatory pseudotumor; plasma cell granuloma.

Publication types

  • Review

MeSH terms

  • Granuloma, Plasma Cell / diagnosis*
  • Granuloma, Plasma Cell / epidemiology
  • Granuloma, Plasma Cell / etiology
  • Granuloma, Plasma Cell / surgery
  • Heart Neoplasms / diagnosis*
  • Heart Neoplasms / epidemiology
  • Heart Neoplasms / etiology
  • Heart Neoplasms / surgery
  • Humans
  • Immunohistochemistry
  • Prognosis
  • Survival Analysis
  • Terminology as Topic