The C-arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso bromination and nitrile substitution in good overall yields.
Keywords: C-arylglycoside; Dötz benzannulation; Fischer carbene complex; Streptomyces sp; ipso bromination.
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