Corneal Deformation Parameters Provided by the Corvis-ST Pachy-Tonometer in Healthy Subjects and Glaucoma Patients

J Glaucoma. 2015 Oct-Nov;24(8):568-74. doi: 10.1097/IJG.0000000000000133.

Abstract

Purpose: To evaluate precision and accuracy of Corvis-ST, a new noncontact tonometer equipped with a high-speed Scheimpflug technology, which measures intraocular pressure (IOP), central corneal thickness (CCT), and corneal deformation parameters (CDPs). Relationships among IOP, CCT, and CDPs were also assessed.

Materials and methods: This prospective, randomized study included 1 eye of 164 subjects (79 controls and 85 glaucoma patients), which underwent IOP measurements taken 3 times with Goldmann applanation tonometry (GAT) and Corvis-ST in random order. Precision was evaluated using intraclass correlation coefficients. Intermethod agreement was assessed using Bland-Altman method. Relationships amongst IOP, CCT and CDPs were evaluated using linear regression analysis.

Results: Corvis-ST intraclass correlation coefficients ranged between 0.95 and 0.99 for IOP and CCT; between 0.17 and 0.97 for CDPs. Mean (GAT-Corvis-ST) IOP was 1.4±2.7 mm Hg, which appeared related to IOP and CDPs (P<0.05). CDPs significantly differed between glaucoma patients and controls (P<0.05). GAT and Corvis-ST IOP was related to CCT (P<0.05) and CDPs (P<0.001).

Conclusions: Corvis-ST precision was excellent for IOP and CCT; moderate for CDPs. Corvis-ST underestimated GAT IOP, especially at higher IOP and at lower corneal deformability levels. GAT and Corvis-ST IOP increased in thicker and less deformable corneas. Glaucoma patients showed significantly less deformable corneas than controls.

Publication types

  • Observational Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antihypertensive Agents / therapeutic use
  • Biomechanical Phenomena
  • Cornea / physiopathology*
  • Corneal Pachymetry
  • Elasticity / physiology*
  • Female
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / physiopathology*
  • Healthy Volunteers
  • Humans
  • Intraocular Pressure / physiology*
  • Male
  • Middle Aged
  • Prospective Studies
  • Tonometry, Ocular / methods

Substances

  • Antihypertensive Agents