Abstract
A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry*
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Benzyl Compounds / chemistry*
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Catalysis
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Cyanides / chemistry*
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Cyclization
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Free Radicals / chemistry*
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Heterocyclic Compounds / chemistry*
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Indicators and Reagents / chemistry
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Indoles / chemistry*
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Methylation
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Molecular Structure
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Phenanthridines / chemistry*
Substances
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Acrylamides
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Benzyl Compounds
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Cyanides
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Free Radicals
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Heterocyclic Compounds
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Indicators and Reagents
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Indoles
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Phenanthridines
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dicumyl peroxide