Progress and peril: poliomyelitis eradication efforts in Pakistan, 1994-2013

J Infect Dis. 2014 Nov 1;210 Suppl 1(Suppl 1):S152-61. doi: 10.1093/infdis/jiu450.

Abstract

Pakistan is one of 3 countries where transmission of indigenous wild poliovirus (WPV) has never been interrupted. Numbers of confirmed polio cases have declined by >90% from preeradication levels, although outbreaks occurred during 2008-2013. During 2012 and 2013, 58 and 93 WPV cases, respectively, were reported, almost all of which were due to WPV type 1. Of the 151 WPV cases reported during 2012-2013, 123 (81%) occurred in the conflict-affected Federally Administered Tribal Areas (FATA) and in security-compromised Khyber Pakhtunkhwa province. WPV type 3 was isolated from only 3 persons with polio in a single district in 2012. During August 2012-December 2013, 62 circulating vaccine-derived poliovirus type 2 cases were detected, including 40 cases (65%) identified in the FATA during 2013. Approximately 350 000 children in certain districts of the FATA have not received polio vaccine during supplementary immunization activities (SIAs) conducted since mid-2012, because local authorities have banned polio vaccination. In other areas of Pakistan, SIAs have been compromised by attacks targeting polio workers, which started in mid-2012. Further efforts to reach children in conflict-affected and security-compromised areas will be necessary to prevent reintroduction of WPV into other areas of Pakistan and other parts of the world.

Keywords: Pakistan; disease eradication; epidemiology; polio; surveillance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Disease Eradication*
  • Disease Outbreaks
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Pakistan / epidemiology
  • Poliomyelitis / epidemiology*
  • Poliomyelitis / prevention & control*
  • Poliovirus / classification
  • Poliovirus / isolation & purification*
  • Poliovirus Vaccines / administration & dosage
  • Vaccination / statistics & numerical data

Substances

  • Poliovirus Vaccines