A novel twist in membrane dePHormation

Dev Cell. 2014 Oct 13;31(1):3-4. doi: 10.1016/j.devcel.2014.09.016.

Abstract

Bin-Amphiphysin-Rvs (BAR) domain-containing proteins form oligomeric assemblies that aid membrane remodeling. In this issue of Developmental Cell, Pang et al. (2014) show that the BAR domain of ACAP1, although architecturally similar to other BAR domains, cooperates with its neighboring pleckstrin homology domain to deform membranes and facilitate endosomal recycling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Membrane / metabolism*
  • GTPase-Activating Proteins / chemistry*
  • Humans

Substances

  • ACAP1 protein, human
  • GTPase-Activating Proteins