Exploring phosphatidylinositol 5-phosphate 4-kinase function

Adv Biol Regul. 2015 Jan:57:193-202. doi: 10.1016/j.jbior.2014.09.007. Epub 2014 Oct 2.

Abstract

The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.

Keywords: Inositide; Kinase; Phosphatidylinositol; Phosphatidylinositol 5-Phosphate4-kinase; Phosphatidylinositol 5-phosphate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Phosphatidylinositol Phosphates / genetics*
  • Phosphatidylinositol Phosphates / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / genetics*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Signal Transduction / physiology*

Substances

  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 5-phosphate
  • Phosphotransferases (Alcohol Group Acceptor)
  • 1-phosphatidylinositol-4-phosphate 5-kinase