Clearance of the intracellular high level of the tau protein directed by an artificial synthetic hydrolase

Mol Biosyst. 2014 Dec;10(12):3081-5. doi: 10.1039/c4mb00508b.

Abstract

Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable 'hydrolase' I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / therapy
  • Copper / chemistry
  • Cyclams
  • Drug Design
  • Heterocyclic Compounds / chemical synthesis
  • Hydrolases / chemical synthesis*
  • Molecular Structure
  • Protein Aggregation, Pathological / prevention & control*
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • tau Proteins / chemistry*

Substances

  • Cyclams
  • Heterocyclic Compounds
  • Recombinant Proteins
  • tau Proteins
  • Copper
  • cyclen
  • Hydrolases