A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Engui Zhao; Haiqin Deng; Sijie Chen; Yuning Hong; Chris Wai Tung Leung; Jacky Wing Yip Lam; Ben Zhong Tang

doi:10.1039/c4cc07128j

A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Chem Commun (Camb). 2014 Nov 28;50(92):14451-4. doi: 10.1039/c4cc07128j.

Authors

Engui Zhao¹, Haiqin Deng, Sijie Chen, Yuning Hong, Chris Wai Tung Leung, Jacky Wing Yip Lam, Ben Zhong Tang

Affiliation

¹ HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China. tangbenz@ust.hk.

PMID: 25302466
DOI: 10.1039/c4cc07128j

Abstract

We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Apoptosis / radiation effects
Biosensing Techniques
Cell Survival / drug effects
Cell Survival / radiation effects
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / pharmacology*
HeLa Cells
Humans
Mitochondria / metabolism
Photochemotherapy
Photosensitizing Agents / chemical synthesis
Photosensitizing Agents / pharmacology*
Quinolinium Compounds / chemical synthesis
Quinolinium Compounds / pharmacology*
Reactive Oxygen Species / metabolism
Ultraviolet Rays

Substances

Fluorescent Dyes
Photosensitizing Agents
Quinolinium Compounds
Reactive Oxygen Species