Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland

Emma Roycroft; Micheál Mac Aogáin; Ronan F O'Toole; Margaret Fitzgibbon; Thomas R Rogers

doi:10.1128/genomeA.01002-14

Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland

Genome Announc. 2014 Oct 9;2(5):e01002-14. doi: 10.1128/genomeA.01002-14.

Authors

Emma Roycroft¹, Micheál Mac Aogáin², Ronan F O'Toole², Margaret Fitzgibbon³, Thomas R Rogers

Affiliations

¹ roycrofe@tcd.ie.
² Department of Clinical Microbiology, Trinity College Dublin, St. James's Hospital, Dublin, Ireland.
³ Irish Mycobacteria Reference Laboratory, Labmed Directorate, St. James's Hospital, Dublin, Ireland.

Abstract

Extensive drug resistance is an emerging threat to the control of tuberculosis (TB) worldwide, even in countries with low TB incidence. We report the draft whole-genome sequence of the first reported extensively drug-resistant TB (XDR-TB) strain isolated in Ireland (a low-incidence setting) and describe a number of single-nucleotide variations that correlate with its XDR phenotype.