Mechanisms of dysfunction of the blood-brain barrier in critically ill patients: emphasis on the role of matrix metalloproteinases

Hugo Rojas; Cristiane Ritter; Felipe Dal Pizzol

Mechanisms of dysfunction of the blood-brain barrier in critically ill patients: emphasis on the role of matrix metalloproteinases

Rev Bras Ter Intensiva. 2011 Jun;23(2):222-7.

[Article in English, Portuguese]

Authors

Hugo Rojas¹, Cristiane Ritter¹, Felipe Dal Pizzol¹

Affiliation

¹ Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.

PMID: 25299724

Abstract

This paper aims to describe the physiological basis of the blood-brain barrier components and its properties. Additionally, the particular effects of metalloproteinases and their control over the extracellular matrix and its relationship with blood-brain barrier dysfunction are discussed. Finally, the role of metalloproteinases on changes in the central nervous system in critically ill patients is discussed.