A general approach to spirolactonized Si-rhodamines

Chem Commun (Camb). 2014 Nov 28;50(92):14374-7. doi: 10.1039/c4cc06178k.

Abstract

A general approach has been developed for the synthesis of spirolactonized Si-rhodamines (SiRBs). The alternative synthetic route provides a facile opportunity to access various s bearing ring-expanded scaffolds and substituents for conjugation. By click reaction, a near-infrared (NIR) mitochondrial tracker was prepared, displaying specific mitochondrial staining in cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Click Chemistry
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology
  • Hep G2 Cells
  • Humans
  • Mice
  • Mitochondria / metabolism
  • Rhodamines / chemistry*
  • Rhodamines / pharmacology
  • Silicon / chemistry*
  • Silicon / pharmacology
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Rhodamines
  • Silicon