Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme

J Mol Model. 2014 Oct;20(10):2465. doi: 10.1007/s00894-014-2465-4. Epub 2014 Oct 9.

Abstract

The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J Mol Model (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.

MeSH terms

  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / metabolism
  • Antiprotozoal Agents / pharmacology*
  • Drug Design*
  • Leishmania / classification
  • Leishmania / drug effects*
  • Leishmania / enzymology
  • Molecular Structure
  • Molecular Targeted Therapy*
  • Peptide Hydrolases* / chemistry
  • Peptide Hydrolases* / metabolism
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / metabolism
  • Protease Inhibitors / pharmacology*
  • Protein Conformation
  • Protozoan Proteins / antagonists & inhibitors*
  • Protozoan Proteins / chemistry
  • Protozoan Proteins / metabolism
  • Structure-Activity Relationship

Substances

  • Antiprotozoal Agents
  • Protease Inhibitors
  • Protozoan Proteins
  • Peptide Hydrolases